Reaktion #353898

Reaktionsgleichung

2-nitroimidazole

potassium carbonate

(S)-(+)-epichlorohydrin

→

(S)-(+)-α-(Chloromethyl)-2-nitro-1H-imidazole-1-ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 10 minutes
2. 2
   Filtrationthen filtered while hot
3. 3
   EinengenThe filtrate is concentrated
4. 4
   Temperaturcooled
5. 5
   Sonstigeto give a solid
6. 6
   SonstigeCrystallization from ethanol and further processing
7. 7
   Sonstigegives the product

Vorschrift

Alternatively, a mixture of 2-nitroimidazole, anhydrous potassium carbonate, and (S)-(+)-epichlorohydrin is refluxed for 10 minutes then filtered while hot. The filtrate is concentrated and cooled to give a solid. Crystallization from ethanol and further processing gives the product.

Quelle