Reaktion #353698

Reaktionsgleichung

1-methylcyclopropylcarbonyl chloride

imidazole

→

1-(1-methylcyclopropylcarbonyl)-imidazole

Ausbeute 91.0%

Lösungsmittel

toluene

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhilst maintaining the temperature below 25° C
2. 2
   Filtrationfiltered
3. 3
   SonstigeThe filtrate was evaporated to dryness

Vorschrift

A solution of 1-methylcyclopropylcarbonyl chloride (11.8 g) in toluene (15 ml) was added dropwise to a solution of imidazole (13.6 g) in tetrahydrofuran (100 ml) whilst maintaining the temperature below 25° C. The mixture was stirred for 3 hours and filtered. The filtrate was evaporated to dryness to give 1-(1-methylcyclopropylcarbonyl)-imidazole (13.6 g) as a white solid, mp 34°-35° C.

Quelle