Reaktion #353669

Reaktionsgleichung

Diisopropylethylamine

4-isopropyl-6,7-dimethoxysaccharin

chloromethyl phenyl sulfide

→

2-phenylthiomethyl-4-isopropyl-6,7-dimethoxysaccharin

Ausbeute 49.0%

Lösungsmittel

dimethylformamide

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with aqueous sodium carbonate solution, hydrochloric acid (3N) and saturated aqueous sodium chloride solution
2. 2
   Trocknendried over sodium sulfate
3. 3
   SonstigePurification of the residue by flash chromatography on silica gel

Vorschrift

Diisopropylethylamine (0.5 mL) was added to a solution of 4-isopropyl-6,7-dimethoxysaccharin (0.5 g) in dimethylformamide (3 mL). After 15 minutes chloromethyl phenyl sulfide (0.35 g) was added. The mixture was heated at 80° C. for 16 hours, diluted with ethyl acetate, washed with aqueous sodium carbonate solution, hydrochloric acid (3N) and saturated aqueous sodium chloride solution, dried over sodium sulfate, and stripped of solvents. Purification of the residue by flash chromatography on silica gel using dichloromethane as eluant gave 2-phenylthiomethyl-4-isopropyl-6,7-dimethoxysaccharin (0.35 g), chlorination of which with sulfuryl chloride (0.1 mL) in dichloromethane (3 mL) and purification of the product by trituration with hexane gave 2-chloremethyl-4-isopropyl-6,7-dimethoxysaccharin, 0.3 g.

Quelle