Reaktion #353549

Reaktionsgleichung

triethylamine

1-methyl-2-chloropyridinium iodide

(RS)-2-(4-chlorobenzenesulfonylamino)-4-methylpentanoic acid

ethyl 4-aminophenylacetate hydrochloride

→

(RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl) phenyl)-4-methylpentanamide

Ausbeute 33.1%

Lösungsmittel

chloroform

Reaktionsbedingungen

Vorschrift

The procedure described in Example 177 was repeated, except that (RS)-2-(4-chlorobenzenesulfonylamino)-4-methylpentanoic acid (1 g) and ethyl 4-aminophenylacetate hydrochloride (635 mg) were condensed in chloroform (30 ml) in the presence of triethylamine (1.82 ml) and 1-methyl-2-chloropyridinium iodide (1 g) to obtain (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl) phenyl)-4-methylpentanamide (455 mg).

Quelle