Reaktion #353543

Reaktionsgleichung

triethylamine

1-methyl-2-chloropyridinium iodide

(R)-2-(4-chlorobenzenesulfonylamino)hexanoic acid

ethyl 4-aminophenylacetate hydrochloride

→

(R)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)hexanamide

Ausbeute 87.0%

Lösungsmittel

chloroform

Reaktionsbedingungen

Vorschrift

The procedure described in Example 177 was repeated, except that (R)-2-(4-chlorobenzenesulfonylamino)hexanoic acid (3 g) and ethyl 4-aminophenylacetate hydrochloride (1.9 g) were condensed in chloroform (100 ml) in the presence of triethylamine (5.4 ml) and 1-methyl-2-chloropyridinium iodide (3.01 g) to obtain as a colorless oily substance (R)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)hexanamide (3.58 g).

Quelle