Reaktion #353537

Reaktionsgleichung

triethylamine

pivaloyl chloride

(RS)-2-(4-chlorobenzenesulfonylamino)-4-phenylbutanoic acid

ethyl 4-aminophenylacetate hydrochloride

→

(RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-4-phenylbutanamide

Ausbeute 46.5%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe resulting crude product was purified by column chromatography (silica gel 50 g, hexane/ethyl acetate=3/1)

Vorschrift

The procedure described in Example 179 was repeated, except that (RS)-2-(4-chlorobenzenesulfonylamino)-4-phenylbutanoic acid (252.0 mg) and ethyl 4-aminophenylacetate hydrochloride (184.3 mg) were condensed in THF (4 ml) in the presence of triethylamine (384.9 μl) and pivaloyl chloride (140.4 μl), and then the resulting crude product was purified by column chromatography (silica gel 50 g, hexane/ethyl acetate=3/1) to obtain (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-4-phenylbutanamide (170.5 mg).

Quelle