Reaktion #351597

Reaktionsgleichung

(R)-1-(7-ethoxy-1,4-dihydro-indeno[1,2-b]pyrrol-1-yl)-propan-2-ol

triethylamine

sodium azide

methanesulfonyl chloride

→

(S)-1-(2-azido-propyl)-7-ethoxy-1,4-dihydro-indeno[1,2-b]pyrrole

Ausbeute 83.9%

Lösungsmittel

dichloromethane

dichloromethane

dimethylformamide

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred at this temperature for an additional 1.5 hours
2. 2
   Waschenwashed twice with 70 ml of saturated sodium hydrogen carbonate solution each time
3. 3
   Extraktionthe combined aqueous phases were extracted once with 70 ml of dichloromethane
4. 4
   WaschenThe combined organic phases were washed with 100 ml of saturated sodium chloride solution
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Sonstigeevaporated in a vacuum
7. 7
   SonstigeThe green oil obtained
8. 8
   Temperaturthe reaction mixture was heated to 60° for 20 hours
9. 9
   workup.STIRRINGwhile stirring
10. 10
    TemperaturAfter cooling
11. 11
    Extraktionextracted three times with 100 ml of ethyl acetate each time
12. 12
    WaschenThe combined organic phases were washed once with 70 ml of water and once with 70 ml of saturated sodium chloride solution
13. 13
    Trocknendried over magnesium sulfate
14. 14
    Einengenthe solution was concentrated in a vacuum
15. 15
    SonstigeThe brown oil obtained
16. 16
    Sonstigewas purified by column chromatography on silica gel (ethyl acetate/hexane 1:10)

Vorschrift

0.59 ml of methanesulfonyl chloride was added dropwise while stirring to a solution, cooled to 0°, of 1.03 g of (R)-1-(7-ethoxy-1,4-dihydro-indeno[1,2-b]pyrrol-1-yl)-propan-2-ol and 2.1 ml of triethylamine in 50 ml of dichloromethane and the mixture was stirred at this temperature for an additional 1.5 hours. The reaction mixture was subsequently diluted with 100 ml of dichloromethane, washed twice with 70 ml of saturated sodium hydrogen carbonate solution each time and the combined aqueous phases were extracted once with 70 ml of dichloromethane. The combined organic phases were washed with 100 ml of saturated sodium chloride solution, dried over magnesium sulfate and evaporated in a vacuum. The green oil obtained was dissolved in 30 ml of anhydrous dimethylformamide, treated with 0.6 g of sodium azide and the reaction mixture was heated to 60° for 20 hours while stirring. After cooling, the solution was poured into 100 ml of water and extracted three times with 100 ml of ethyl acetate each time. The combined organic phases were washed once with 70 ml of water and once with 70 ml of saturated sodium chloride solution, dried over magnesium sulfate and the solution was concentrated in a vacuum. The brown oil obtained was purified by column chromatography on silica gel (ethyl acetate/hexane 1:10). 948 mg (72%) of (S)-1-(2-azido-propyl)-7-ethoxy-1,4-dihydro-indeno[1,2-b]pyrrole were obtained as a light yellowish oil.

Quelle