Reaktion #3511

Reaktionsgleichung

hydrogen

hydrogen

6-bromo-2,4-diamino-5-cyanopyridine

potassium acetate

methanol

→

2,4-diamino-5-cyanopyridine

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvents were removed under reduced pressure
2. 2
   Sonstigethe residue crystallized from isopropyl alcohol

Vorschrift

A suspension of 21.3 g of 6-bromo-2,4-diamino-5-cyanopyridine (JACS, 80:2838-2840 (1958)) and 1 g of 20% palladium on charcoal in 250 mL of tetrahydrofuran was shaken in a Parr apparatus under an atmosphere hydrogen. After 2 hours, the reaction was stopped and 10 g of potassium acetate and 50 mL of methanol added. The reaction was recharged with hydrogen and shaken for 18 hours. The solvents were removed under reduced pressure and the residue crystallized from isopropyl alcohol to afford the title compound 2,4-diamino-5-cyanopyridine, mp 201°-202° C.

Quelle