Reaktion #350933

ord-d5407f3d38f3441987ef4e0f34a9b935

Reaktionsgleichung

C[C@]1(/C=C/c2ccccn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
(E)-(2S,3S,5R)-3-methyl-3-(2-pyridin-2-yl- vinyl)-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
[Br-].[K+]
KBr
[Na]
sodium
→
C[C@]1(/C=C/c2ccccn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O.[Na]
Sodium (E)-(2S,3S,5R)-3-methyl-3-(2-pyridin-2-yl-vinyl)-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Edukte

C[C@]1(/C=C/c2ccccn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
(E)-(2S,3S,5R)-3-methyl-3-(2-pyridin-2-yl- vinyl)-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
—
8.14
[Br-].[K+]
KBr
—
( 344.317 )
—
8.17
[Na]
sodium

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

83 mg (0.17 mmol) of (E)-(2S,3S,5R)-3-methyl-3-(2-pyridin-2-yl- vinyl)-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid were converted into the corresponding sodium salt analogously to Example 10. Yield: 89 mg (100%) of colorless lyophilizate IR (KBr): 1784, 1629, 1587, 1478, 1396, 1320, 1187, 1141, 980 cm-1Elementary analysis: C14H13N2O5SNa (344.317) Calc. C 48.84 H 3.81 N 8.14 Found#) C 49.18 H 4.23 N 8.17 #) anhydrous, calculated with 6.86% water

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05644053uspto-grants-1997_07