Reaktion #350932

ord-ad948da270fb4331bd2ada9338d4baa5

Reaktionsgleichung

C[C@]1(/C=C/c2ccccn2)[C@H](C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C[C@H]2S1(=O)=O
benzhydryl (E)-(2S,3S,5R)-3-methyl-3-(2- pyridin-2-yl-vinyl)-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]-heptane-2-carboxylate
[Br-].[K+]
KBr
→
C[C@]1(/C=C/c2ccccn2)[C@H](C(=O)O)N2C(=O)C[C@H]2S1(=O)=O
(E)-(2S,3S,5R)-3-Methyl-3-(2-pyridin-2-yl-vinyl)-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Edukte

C[C@]1(/C=C/c2ccccn2)[C@H](C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C[C@H]2S1(=O)=O
benzhydryl (E)-(2S,3S,5R)-3-methyl-3-(2- pyridin-2-yl-vinyl)-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]-heptane-2-carboxylate
—
pale beige crystal
[Br-].[K+]
KBr

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

200 mg (0.41 mmol) of benzhydryl (E)-(2S,3S,5R)-3-methyl-3-(2- pyridin-2-yl-vinyl)-4,4,7-trioxo-4-thia-1-aza-bicyclo[3.2.0]-heptane-2-carboxylate were deprotected analogously to Example 10. Yield: 85 mg (65%) of pale beige crystal powder MS: (M+H)+ 323.3 IR (KBr): 2700(br), 1790, 1720, 1621, 1318, 1140, 978 cm-1

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05644053uspto-grants-1997_07