Reaktion #350770

Reaktionsgleichung

potassium 3-[2-(3,4-diethoxyphenyl)thiazole-4-yl]-6-acetylaminobenzoate

→

2-(3,4-diethoxyphenyl)-4-(3-carboxy-4-aminophenyl)thiazole

Ausbeute 20.3%

Lösungsmittel

water

potassium hydroxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwith heating
2. 2
   SonstigeAfter the completion of a reaction
3. 3
   Sonstigethe solvent was removed by distillation
4. 4
   Extraktionextracted with 80 ml of ethyl acetate
5. 5
   WaschenThe extract was washed with 20 ml of a saturated aqueous sodium chloride solution
6. 6
   Sonstigedried
7. 7
   workup.DISTILLATIONsubjected to distillation
8. 8
   Sonstigeto remove the solvent
9. 9
   SonstigeThe residue was recrystallized from ethyl acetate

Vorschrift

A solution of 1 g of potassium 3-[2-(3,4-diethoxyphenyl)thiazole-4-yl]-6-acetylaminobenzoate in 50 ml of water and 10 ml of 30% potassium hydroxide was refluxed for 8 hours with heating. After the completion of a reaction, the solvent was removed by distillation. The residue was made weakly acidic with 10% hydrochloric acid and extracted with 80 ml of ethyl acetate. The extract was washed with 20 ml of a saturated aqueous sodium chloride solution, dried and subjected to distillation to remove the solvent. The residue was recrystallized from ethyl acetate to obtain 168 mg of 2-(3,4-diethoxyphenyl)-4-(3-carboxy-4-aminophenyl)thiazole.

Quelle