Reaktion #350755

Reaktionsgleichung

2-(4-ethoxycarbonylphenyl)-4-(3,4-dihydrocarbostyril-6-yl)thiazole

potassium hydroxide

→

2-(4-carboxyphenyl)-4-(3,4-dihydrocarbostyril-6-yl)thiazole

Ausbeute 36.9%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe suspension was refluxed for 5 hours
2. 2
   SonstigeEthanol was removed by distillation
3. 3
   TemperaturAfter cooling
4. 4
   workup.ADDITIONthe residue was mixed with hydrochloric acid
5. 5
   FiltrationThe resulting crystals were collected by filtration
6. 6
   Sonstigerecrystallized from dimethylformamide

Vorschrift

2.05 g of 2-(4-ethoxycarbonylphenyl)-4-(3,4-dihydrocarbostyril-6-yl)thiazole was suspended in 20 ml of a 10% aqueous potassium hydroxide solution and 50 ml of ethanol. The suspension was refluxed for 5 hours. Ethanol was removed by distillation. After cooling, the residue was mixed with hydrochloric acid to make it acidic (pH 1). The resulting crystals were collected by filtration and recrystallized from dimethylformamide to obtain 0.70 g of 2-(4-carboxyphenyl)-4-(3,4-dihydrocarbostyril-6-yl)thiazole as a light yellow powder.

Quelle