Reaktion #350670

ord-aaa8e01f8a8c4a3eb9c986d6e44557fc

Reaktionsgleichung

CC(=O)N(N1C(=O)C(NC(=O)C(N)Cc2ccccc2)CC(c2ccccc2)CC1c1ccccc1)C(C)(C)C
1-(N-t-butylacetamido)-3-(2-amino-3-phenylpropionamido)-5,7-diphenylhexahydroazepin-2-one
→
CC(=O)N(N1C(=O)C(N)CC(c2ccccc2)CC1c1ccccc1)C(C)(C)C
(+)-1-(N-t-butylacetamido)-3-amino-5,7-diphenylhexahydroazepin-2-one
Ausbeute 92.0%

Edukte

CC(=O)N(N1C(=O)C(NC(=O)C(N)Cc2ccccc2)CC(c2ccccc2)CC1c1ccccc1)C(C)(C)C
1-(N-t-butylacetamido)-3-(2-amino-3-phenylpropionamido)-5,7-diphenylhexahydroazepin-2-one

Reagenzien

Keine

Lösungsmittel

CCOC(C)=O
ethyl acetate

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared as above from 1-(N-t-butylacetamido)-3-(2-amino-3-phenylpropionamido)-5,7-diphenylhexahydroazepin-2-one (less polar isomer) as an oil in 92% yield, αD =+3.21° (c=0.8, ethyl acetate). The 1H-NMR spectrum matches that of the racemate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05643904uspto-grants-1997_07