Reaktion #350563

Reaktionsgleichung

5-amino-2-chloro-4-fluorophenol

2-bromopropane

potassium carbonate

→

title compound

Ausbeute 62.0%

4-Chloro-2-fluoro-5-(1 -methylethoxy)aniline

Ausbeute 62.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux for 17 h
3. 3
   TemperaturThe reaction mixture was cooled
4. 4
   Filtrationfiltered
5. 5
   SonstigeThe filtrate was evaporated to dryness under reduced pressure

Vorschrift

A stirring mixture of 5-amino-2-chloro-4-fluorophenol (22.0 g, 136.19 mmol), 2-bromopropane (38.4 mL, 50.25 g, 408.57 mmol) and potassium carbonate (37.6 g, 273.0 mmol) was heated at reflux for 17 h. The reaction mixture was cooled and filtered. The filtrate was evaporated to dryness under reduced pressure. Flash chromatography yielded the title compound of Step A as a brown oil (17.2 g). 1H NMR (CDCl3): δ7.02 (d, 1H), 6.44 (d, 1H) 4.38 (q, 1H), 3.81 (br s,2H), 1.33 (d,6H). IR (cm-1): 3378.4, 3475.6.

Quelle