Reaktion #350216

Reaktionsgleichung

potassium carbonate

O,O-dimethyl chlorothiophosphate

2-cyano-3-hydroxy-5-n-butoxy-thiophene

→

2-cyano-3-(dimethoxythiophosphoryloxy)-5-n-butoxy-thiophene

Ausbeute 68.9%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationwas then filtered
2. 2
   SonstigeThe filtrate was evaporated to dryness
3. 3
   Sonstigethe residue was chromatographed over silica gel
4. 4
   WaschenElution with benzene

Vorschrift

7 g of potassium carbonate and 8 g of O,O-dimethyl chlorothiophosphate were added to a solution of 9.8 g of 2-cyano-3-hydroxy-5-n-butoxy-thiophene in 150 ml of acetonitrile and the mixture was stirred for 24 hours at 20° C. and was then filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica gel. Elution with benzene yielded 11 g of 2-cyano-3-(dimethoxythiophosphoryloxy)-5-n-butoxy-thiophene with a refractive index of nD20 =1.5375.

Quelle