Reaktion #3502

Reaktionsgleichung

water

potassium carbonate

chloromethylpropargyl ether

N-methoxybenzamide

→

N-methoxy-N-propargyloxymethylbenzamide

Ausbeute 91.9%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   Extraktionthe mixture was extracted with ethyl acetate
3. 3
   SonstigeThe extract was dried
4. 4
   Einengenconcentrated
5. 5
   Sonstigepurified by silica gel column chromatography

Vorschrift

0.6 g of N-methoxybenzamide was dissolved in 10 ml of acetonitrile, and 0.55 g of potassium carbonate and 0.42 g of chloromethylpropargyl ether were added thereto in this order. The mixture was stirred at room temperature for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.8 g of N-methoxy-N-propargyloxymethylbenzamide.

Quelle