Reaktion #349683

Reaktionsgleichung

5-(3-pyridylmethyl)-2-methylthio-4-pyrimidone

2-(5-methyl-4-imidazolylmethylthio)-ethylamine

→

2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated at 130°-135° for 7 hours
2. 2
   SonstigeThe cool mixture was triturated with hot water

Vorschrift

An intimate mixture of 5-(3-pyridylmethyl)-2-methylthio-4-pyrimidone (6.55 g) and 2-(5-methyl-4-imidazolylmethylthio)-ethylamine (4.8 g) was heated at 130°-135° for 7 hours. The cool mixture was triturated with hot water to give 2-[2-(5-methyl-4-imidazolylmethylthio)-ethylamino]-5-(3-pyridylmethyl)-4-pyrimidone and this product was treated with dilute ethanolic HCl to give the title compound m.p. 237°-241° (ethanol-water)

Quelle