Reaktion #349680

Reaktionsgleichung

5-(2-thienylmethyl)-2-methylthio-4-pyrimidone

2-(5-methyl- 4-imidazolylmethylthio)ethylamine

→

2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-thienylmethyl)-4-pyrimidone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated at 140° for 6 hours
2. 2
   WaschenThe cooled residue was washed with water

Vorschrift

An intimate mixture of 5-(2-thienylmethyl)-2-methylthio-4-pyrimidone (1.43 g) and 2-(5-methyl- 4-imidazolylmethylthio)ethylamine (1.03 g) was heated at 140° for 6 hours. The cooled residue was washed with water to give 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-thienylmethyl)-4-pyrimidone, and this product was treated with dilute ethanolic HCl to give the title compound in 40% yield, m.p. 172°-176° (ethanol-acetonitrile). The dihydrochloride was passed down an ion-exchange column of IRA 400 eluting with 1 N hydrobromic acid, and the eluate was evaporated to dryness and recrystallised from ethanol acetonitrile to give the corresponding dihydrobromide m.p. 199°-203°.

Quelle