Reaktion #3491

Reaktionsgleichung

KOH

6-chloropurine

HCl

3,5-diacetylaniline

→

6-[(3,5-diacetylphenyl)amino]purine

Ausbeute 90.4%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturat reflux for 30 min
3. 3
   TemperaturAfter cooling the mixture
4. 4
   Filtrationthe solid was filtered out
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried

Vorschrift

Compound No. 16: A suspension of 3,5-diacetylaniline (0.531 g) in water (10 mL) was treated with 6-chloropurine (0.464 g) and concentrated HCl (0.25 mL) and heated at reflux for 30 min. After cooling the mixture was treated with 6 mL of aqueous 1N KOH. The mixture was stirred for 10 min and the solid was filtered out, washed with water, and dried, to give 0.80 g of 6-[(3,5-diacetylphenyl)amino]purine, mp dec 340°-350° C.

Quelle