Reaktion #349072

ord-4588e6aa34e34c93a7fcf532860d1da3

Reaktionsgleichung

NC1CCCCC1N1CCC(O)C1
2-(3-hydroxy-1-pyrrolidinyl)cyclohexylamine
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
O=C(O)c1ccc(Cl)c(Cl)c1
3,4-dichlorobenzoic acid
→
CN(C(=O)c1ccc(Cl)c(Cl)c1)C1CCCCC1N1CCC(O)C1
N-methyl-N-[2-(3-hydroxy-1-pyrrolidinyl)cyclohexyl]-3,4-dichlorobenzamide

Edukte

NC1CCCCC1N1CCC(O)C1
2-(3-hydroxy-1-pyrrolidinyl)cyclohexylamine
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
O=C(O)c1ccc(Cl)c(Cl)c1
3,4-dichlorobenzoic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure of Example 1a, using trans-N-methyl-N-[2-(3-hydroxy-1-pyrrolidinyl)cyclohexylamine, carbonyldiimidazole] and 3,4-dichlorobenzoic acid there is obtained N-methyl-N-[2-(3-hydroxy-1-pyrrolidinyl)cyclohexyl]-3,4-dichlorobenzamide.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04152459uspto-grants-1979_05