Reaktion #3489

ord-74a2ccfcddee49eb8680c2a9e7272626

Reaktionsgleichung

CC(=O)c1cccc(Nc2cc(C)nc(N)n2)c1
4-(3-acetylphenyl)amino-2-amino-6methylpyrimidine
CI
methyl iodide
→
CC(=O)c1cccc(Nc2cc(C)[n+](C)c(N)n2)c1.[I-]
4-(3-acetylphenyl)amino-2-amino-1,6-dimethylpyrimidinium iodide

Edukte

CC(=O)c1cccc(Nc2cc(C)nc(N)n2)c1
4-(3-acetylphenyl)amino-2-amino-6methylpyrimidine
CI
methyl iodide

Reagenzien

Keine

Lösungsmittel

CC(C)=O
acetone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturwas heated
  2. 2
    Temperaturat reflux for 48 hr
  3. 3
    FiltrationFiltration
  4. 4
    Temperaturafter cooling

Vorschrift

Compound No. 14: 4-(3-acetylphenyl)amino-2-amino-6methylpyrimidine, Compound No. 15, (0.968 g) was suspended in acetone (5 mL) containing methyl iodide (2 mL) was heated at reflux for 48 hr. Filtration after cooling gave 0.657 g of 4-(3-acetylphenyl)amino-2-amino-1,6-dimethylpyrimidinium iodide as a white powder, mp 238°-40° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05733932uspto-grants-1998_03