Reaktion #348197

Reaktionsgleichung

N-amidino-3,5-diamino-6-chloropyrazinamide

DBN

dimethylformamide

diethyl chlorophosphite

→

diethyl N-[(3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   workup.ADDITIONtreated with ice water (300 ml.)

Vorschrift

A stirred solution of N-amidino-3,5-diamino-6-chloropyrazinamide (4.6 g., 0.02 mole) and DBN (2.5 g., 0.02 mole) in dimethylformamide (300 ml.) is cooled to 10° C. and treated with diethyl chlorophosphite (2.9 ml., 0.02 mole). The reaction is stirred at 25° C. for 3 hours, filtered and treated with ice water (300 ml.) to give diethyl N-[(3,5-diamino-6-chloro-pyrazinamido)iminomethyl]phosphoramidate which melts at 230° C. after recrystallization from ethanol-water.

Quelle