Reaktion #348196

Reaktionsgleichung

N-amidino-3-amino-5-isopropylamino-6-chloropyrazinecarboxamide

DBN

tetrahydrofuran

diethyl chlorophosphite

→

diethyl N-[(3-amino-6-chloro-5-isopropylaminopyrazinamido)iminomethyl]phosphoramidate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture is filtered
2. 2
   Sonstigeevaporated to a volume of 5 ml
3. 3
   workup.ADDITIONand treated with water (100 ml.)

Vorschrift

A stirred solution of N-amidino-3-amino-5-isopropylamino-6-chloropyrazinecarboxamide (2.7 g., 0.01 mole) and DBN (1.24 g., 0.01 mole) in tetrahydrofuran (100 ml.) is cooled to 10° C., treated with diethyl chlorophosphite (1.44 ml., 0.01 mole), then stirred at 25° for one hour. The reaction mixture is filtered evaporated to a volume of 5 ml. and treated with water (100 ml.) to give diethyl N-[(3-amino-6-chloro-5-isopropylaminopyrazinamido)iminomethyl]phosphoramidate which melts at 166° C. after recrystallization from isopropanol-water.

Quelle