Reaktion #3478

Reaktionsgleichung

1-[2-(tert-Butoxycarbonylamino)-5-methoxyphenyl]-2-butanone

→

2-ethyl-5-methoxy-1H-indole

Ausbeute 58.0%

Lösungsmittel

CH2Cl2

trifluoroacetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water, NaHCO3 solution
2. 2
   Sonstigethe product chromatographed on silica (eluted with 20% EtOAc/hexane)

Vorschrift

1-[2-(tert-Butoxycarbonylamino)-5-methoxyphenyl]-2-butanone (7.33 g, 0.025 mol) in 120 mL of CH2Cl2 and 20 mL of trifluoroacetic acid was stirred for 20 hours, washed with water, NaHCO3 solution and the product chromatographed on silica (eluted with 20% EtOAc/hexane) to give 2.54 g (58% yield) of 2-ethyl-5-methoxy-1H-indole as a white solid, mp 49°-50° C.

Quelle