Reaktion #347765

Reaktionsgleichung

aluminum chloride

phenol

2,5-dichloro-2,5-dimethylhexane

→

title compound

Ausbeute 32.1%

5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthol

Ausbeute 32.1%

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ether
2. 2
   Waschenthe organic phase was washed
3. 3
   Trocknendried over sodium sulfate
4. 4
   Sonstigeevaporated under reduced pressure
5. 5
   SonstigeTwo recrystallizations of the residue from methanol

Vorschrift

27.5 g (0.2 mol) of anhydrous aluminum chloride were added by spatula to 250.0 g (2.65 mol) of phenol plus 414.5 g (2.27 mol) of 2,5-dichloro-2,5-dimethylhexane in 500 ml of petroleum ether at room temperature while stirring. After 48 hours, the reaction mixture was poured into ice-water and extracted with ether, and the organic phase was washed to neutrality with water, dried over sodium sulfate and evaporated under reduced pressure. Two recrystallizations of the residue from methanol yielded 148.7 g of the title compound of melting point 219°-220° C.

Quelle