Reaktion #346496

Reaktionsgleichung

ethyl isocyanate

4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride

→

1-ethyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

Reaktionsbedingungen

Vorschrift

In the manner described in Example 1, ethyl isocyanate is allowed to react with 4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride to afford 10.1 grams of 1-ethyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea. Recrystallization of the crude product from 2-propanol-water (9/1) affords crystals which are dissolved in chloroform and washed successively with 1N sulfuric acid, water and saturated sodium bicarbonate solution. This gives the desired product, melting point 184° C. to 188.5° C. after evaporation of the chloroform.

Quelle