Reaktion #346297

Reaktionsgleichung

1,2,3a, 4,5,6-hexahydro-7,8-dimethoxypyrano[2,3,4-de]isoquinoline

acetic anhydride

pyridine

→

title compound

5-Acetyl-1,2,3a,4,5,6-hexahydro-7,8-dimethoxypyrano[2,3,4-de]isoquinoline

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated on the steam bath for 4 hr
2. 2
   ExtraktionThe mixture is extracted with chloroform
3. 3
   Waschenthe extracts are washed with sodium bicarbonate solution
4. 4
   SonstigeThe organic solution is dried
5. 5
   Sonstigeevaporated

Vorschrift

A mixture of 1,2,3a, 4,5,6-hexahydro-7,8-dimethoxypyrano[2,3,4-de]isoquinoline (10.0 g), described in Example 56, acetic anhydride (60.0 ml) and pyridine (0.5 ml) is heated on the steam bath for 4 hr. The mixture is poured into water and stirred for 2 hr. The mixture is extracted with chloroform and the extracts are washed with sodium bicarbonate solution and then with brine. The organic solution is dried and evaporated to leave the title compound. A sample, crystallized from isopropanol, had m.p. 100°- 102° C.

Quelle