Reaktion #3461

Reaktionsgleichung

1-[(3-chlorophenyl)methyl]-2-ethyl-4-hydroxy-1H-indole

NaH

methyl bromoacetate

→

[[1-[(3-chlorophenyl)methyl]-2-ethyl-1H-indol-4-yl]oxy]acetic acid methyl ester

Ausbeute 65.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was purified by chromatography over silica gel eluting with 20% EtOAc/hexane

Vorschrift

Using the procedure described in Example 1, Part E, 1-[(3-chlorophenyl)methyl]-2-ethyl-4-hydroxy-1H-indole (512 mg, 1.8 mmol) was treated with 72 mg (1.8 mmol) of 60% NaH/mineral oil and then 0.17 mL (1.8 mmol) of methyl bromoacetate. The product was purified by chromatography over silica gel eluting with 20% EtOAc/hexane, to give 418 mg (65% yield) of [[1-[(3-chlorophenyl)methyl]-2-ethyl-1H-indol-4-yl]oxy]acetic acid methyl ester, mp, 85°-90° C.

Quelle