Reaktion #345786

ord-ef9f38ad3d2743dfacc6d4cb74aae0a9

Reaktionsgleichung

CCCCCC(CCCN(CCCCCCC(=O)OCC)S(=O)(=O)C(C)C)OC(C)=O
ethyl 7-[N-(4-acetoxynonyl)-1-methylethanesulfonamido]heptanoate
CCOC(=O)CCCCCCNS(C)(=O)=O
ethyl 7-(methanesulfonamido)heptanoate
→
CCCCC[C@@H](O)C#CCN(CCCCCCC(=O)O)S(C)(=O)=O
7-[N-(4-hydroxynonyl)-1-methylethanesulfonamido]heptanoic acid
CCCCC[C@@H](O)C#CCN(CCCCCCC(=O)O)S(C)(=O)=O
7-[N-(4(R)-hydroxy-2-nonynyl)methanesulfonamido]heptanoic acid

Edukte

CCCCCC(CCCN(CCCCCCC(=O)OCC)S(=O)(=O)C(C)C)OC(C)=O
ethyl 7-[N-(4-acetoxynonyl)-1-methylethanesulfonamido]heptanoate
CCOC(=O)CCCCCCNS(C)(=O)=O
ethyl 7-(methanesulfonamido)heptanoate
—
ethyl 7-[(1-methylethane)sulfonamido]heptanoate
—
product

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe synthesis of this compound

Vorschrift

The synthesis of this compound is carried out as described in Example 1 except that, in Step A, the ethyl 7-(methanesulfonamido)heptanoate is replaced by an equimolar amount of ethyl 7-[(1-methylethane)sulfonamido]heptanoate (Example R). The product of Step A is thus ethyl 7-[N-(4-acetoxynonyl)-1-methylethanesulfonamido]heptanoate. The subsequent step yields 7-[N-(4-hydroxynonyl)-1-methylethanesulfonamido]heptanoic acid (B).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04033996uspto-grants-1977_07