Reaktion #345378

Reaktionsgleichung

Ethyl α-nitro-5H-dibenzo[a,d]cycloheptene-5-acetate

water

hydrochloric acid

→

Ethyl α-Amino-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-acetate hydrochloride

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschena white solid washed with diethyl ether
2. 2
   Sonstigedried at 50° C./2 mm Hg

Vorschrift

Ethyl α-nitro-5H-dibenzo[a,d]cycloheptene-5-acetate (13 g, 40 mmol) (Example 4, Step A) is dissolved in 150 mL of ethanol, 40 mL of water, and 3.5 mL of concentrated hydrochloric acid and hydrogenated with 2.0 g of 20% palladium on carbon (52 psi, 30 hours). The filtered solution is stripped and a white solid washed with diethyl ether, dried at 50° C./2 mm Hg. The crude product is used as is in the next step.

Quelle