Reaktion #344925

Reaktionsgleichung

olefin

5-(N-Acetylindol-3-yl)pent-2-enoic acid ethyl ester

benzylamine

→

adduct 33

Ausbeute 79.9%

N-Benzyl-3-[2-(indol-3-yl)ethyl]β-alanine ethyl ester

Ausbeute 79.9%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe cooled reaction mixture

Vorschrift

A mixture of olefin 32 (5.0 g, 17.5 mmol) and benzylamine (7.7 mL, 70 mmol) was heated at 80° C. for 20 hours. The cooled reaction mixture was applied directly to a flash chromatography column (silica, 30% ethyl acetate/hexanes) to give the Micheal adduct 33 (4.9 g) as a viscous yellow oil.

Quelle