Reaktion #344614

Reaktionsgleichung

3-chloro-3-methyl-1-butyne

NaOH

methyl 4-(acetylamino]-2-hydroxybenzoate

sodium hydride

potassium iodide

→

methyl 4-(acetylamino)-2-(1,1-dimethyl-2-propynyloxy)benzoate

Ausbeute 10.1%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe whole was stirred for 24 hours at 90° C.
2. 2
   ExtraktionThe product was extracted with dichloromethane
3. 3
   Sonstigethe extract was dried
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated
6. 6
   workup.STIRRINGThe residue was successively stirred in petroleumether
7. 7
   workup.DISSOLUTIONdissolved in dichloromethane
8. 8
   WaschenThe latter solution was washed with water, NaOH 10% and water
9. 9
   Sonstigewas then dried
10. 10
    Filtrationfiltered
11. 11
    Sonstigeevaporated
12. 12
    SonstigeThe residue was purified by column chromatography (silica gel; CH2Cl2)
13. 13
    SonstigeThe eluent of the desired fraction was evaporated

Vorschrift

To a solution of 310 parts of methyl 4-(acetylamino]-2-hydroxybenzoate in 2820 parts of N,N-dimethylformamide there were added portion wise 71 parts of a dispersion of sodium hydride in mineral oil (50%) and, after stirring for 1 hour at room temperature, one crystal of potassium iodide and 172 parts of 3-chloro-3-methyl-1-butyne under a nitrogen atmosphere. The whole was stirred for 24 hours at 90° C. and was then poured into NaOH 10% (aq.). The product was extracted with dichloromethane and the extract was dried, filtered and evaporated. The residue was successively stirred in petroleumether and dissolved in dichloromethane. The latter solution was washed with water, NaOH 10% and water and was then dried, filtered and evaporated. The residue was purified by column chromatography (silica gel; CH2Cl2). The eluent of the desired fraction was evaporated, yielding in two fractions 41 parts (10.1%) of methyl 4-(acetylamino)-2-(1,1-dimethyl-2-propynyloxy)benzoate (interm. 1).

Quelle