Reaktion #343979

Reaktionsgleichung

DL-2-hydroxycaproic acid

decyl alcohol

→

clear colorless liquid

Ausbeute 49.0%

Decyl 2-Hydroxyhexanoate

Ausbeute 49.0%

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewater collected as the reaction
2. 2
   Waschenby washing three times with 50 ml saturated sodium bicarbonate solution
3. 3
   SonstigeThe organic layer was collected
4. 4
   Trocknendried over magnesium sulfate
5. 5
   SonstigeExcess decyl alcohol was removed by high vacuum distillation

Vorschrift

A 50 ml one neck round bottom flask equipped with a Dean Stark trap, condenser and a nitrogen inlet/outlet was charged with 5.0 g (0.038 moles) DL-2-hydroxycaproic acid, 23.95 g (0.151 moles) decyl alcohol, and 0.019 g sulfuric acid. The reactants were heated to 140° C. for 8 hours and water collected as the reaction proceeded. The acid was neutralized by washing three times with 50 ml saturated sodium bicarbonate solution. Approximately 50 ml ether was needed to break the emulsion. The organic layer was collected and dried over magnesium sulfate. Excess decyl alcohol was removed by high vacuum distillation to yield 4.34 g (49% yield) of clear colorless liquid. According to GC the product is 95.74% pure.

Quelle