Reaktion #343965

Reaktionsgleichung

sodium bicarbonate

p-bromophenol

1 -adamantanol

sulfuric acid

→

2-(1-adamantyl)-4-bromophenol

Lösungsmittel

dichloromethane

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with methylene chloride
2. 2
   Sonstigedried
3. 3
   Sonstigeevaporated
4. 4
   SonstigeAfter recrystallization in isooctane 52.8 g of the expected product
5. 5
   Sonstigeare obtained
6. 6
   SonstigeYield--86%

Vorschrift

34.6 g (200 mmol) of p-bromophenol and 30.4 g (200 mmol) of 1 -adamantanol are dissolved in 100 ml of dichloromethane. To the resulting solution there are slowly added 10 ml of concentrated sulfuric acid. The mixture is stirred for 8 hours at ambient temperature poured into water, neutralized with sodium bicarbonate, extracted with methylene chloride, dried and evaporated. After recrystallization in isooctane 52.8 g of the expected product are obtained. Yield--86%. Melting point: 140°-141° C.

Quelle