Reaktion #343693

ord-083540e260744b8b94717887f3bd53ce

Reaktionsgleichung

O=P([O-])(O)O.[K+]
potassium dihydrogenphosphate
OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@H](O)[C@@H]1O
inosine
c1c[nH]nn1
triazole
O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
uridine
Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1
cytidine
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
adenosine
NC(=O)c1nc[nH]n1
1, 2, 4-triazole-3-carboxamide
Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
guanosine
→
NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)n1
ribavirin

Edukte

—
solution
O=P([O-])(O)O.[K+]
potassium dihydrogenphosphate
OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@H](O)[C@@H]1O
inosine
c1c[nH]nn1
triazole
O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
uridine
Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1
cytidine
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
adenosine
—
saccharide
NC(=O)c1nc[nH]n1
1, 2, 4-triazole-3-carboxamide
Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1
guanosine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

By using a substrate solution (pH 6.0) containing 40 mM 1, 2, 4-triazole-3-carboxamide (hereinafter called "triazole") as the base donor, 40 mM uridine, inosine, cytidine, adenosine or guanosine as the saccharide residue donor and 40 mM potassium dihydrogenphosphate, ribavirin was produced in the same manner as in Example 1. The results are shown in Table 7.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05258301uspto-grants-1993_11