Reaktion #343608

Reaktionsgleichung

Trichloroisocyanuric acid

ethyl 2-(2-formamidothiazol-4-yl)-2-methoxyiminoacetate

water

→

ethyl 2-(2-formamido-5-chlorothiazol-4-yl)-2-methoxyiminoacetate

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONThe reaction mixture was poured
2. 2
   Filtrationthe precipitates were collected by filtration
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried

Vorschrift

Trichloroisocyanuric acid (6.7 g.) was added portionwise to a chilled solution of ethyl 2-(2-formamidothiazol-4-yl)-2-methoxyiminoacetate (syn isomer, 20.0 g.) in dry dimethylformamide (400 ml.) and stirred at room temperature for 2 hrs. The reaction mixture was poured into chilled water (2 l.), and the precipitates were collected by filtration, washed with water and dried to give ethyl 2-(2-formamido-5-chlorothiazol-4-yl)-2-methoxyiminoacetate (syn isomer, 18.9 g.).

Quelle