Reaktion #343428

Reaktionsgleichung

2,2,5,5-Tetramethyl-1-cyclopentylmethanol

phosphorus tribromide

→

2,2,5,5-Tetramethyl-1-cyclopentylmethyl bromide

Lösungsmittel

benzene

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture is stirred for 2 hours
2. 2
   Temperaturheated to 60° C. for 4 hours
3. 3
   TemperaturThe mixture is cooled
4. 4
   workup.ADDITIONpoured into ice
5. 5
   Extraktionextracted with ether
6. 6
   WaschenThe organic layer is washed with saturated NaHCO3
7. 7
   Trocknendried over MgSO4
8. 8
   Sonstigeevaporated

Vorschrift

2,2,5,5-Tetramethyl-1-cyclopentylmethanol is dissolved in benzene and stirred at 0° C. under argon. A solution of phosphorus tribromide in benzene is added and the mixture is stirred for 2 hours and then heated to 60° C. for 4 hours. The mixture is cooled, poured into ice and extracted with ether. The organic layer is washed with saturated NaHCO3, dried over MgSO4 and evaporated to yield 2,2,5,5-Tetramethyl-1-cyclopentylmethyl bromide.

Quelle