Reaktion #343310

Reaktionsgleichung

2-Amino-2,3-dimethylbutyramide

furo[2,3-b]pyridine-5,6-dicarboxylic acid anhydride

ether

→

6-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]furo[2,3-b]pyridine-5-carboxylic acid

Ausbeute 97.9%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe reaction mixture is then stirred at 60° C. for one hour
2. 2
   Temperaturcooled to room temperature
3. 3
   Filtrationthe solid filtered off
4. 4
   Sonstigedried

Vorschrift

2-Amino-2,3-dimethylbutyramide (2.1 g, 0.016 mol) is added to a stirred suspension of furo[2,3-b]pyridine-5,6-dicarboxylic acid anhydride (3.0 g, 0.016 mol) in tetrahydrofuran (7.5 mL) and the mixture allowed to stir at room temperature for 16 hours. The reaction mixture is then stirred at 60° C. for one hour, cooled to room temperature, ether added, and the solid filtered off and dried to give 5 g of 6-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]furo[2,3-b]pyridine-5-carboxylic acid mp 192°-196° C. (dec).

Quelle