Reaktion #343303

Reaktionsgleichung

2-Amino-2,3-dimethylbutyramide

thieno[2,3-b]pyridine-5,6-dicarboxylic acid anhydride

N2

→

6-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]thieno[2,3-b]pyridine-5-carboxylic acid

Ausbeute 72.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe resulting solid filtered off
2. 2
   Waschenwashed with THF and air
3. 3
   Sonstigedried

Vorschrift

2-Amino-2,3-dimethylbutyramide (9.84 g, 0.076 mol) is added to a stirred suspension of thieno[2,3-b]pyridine-5,6-dicarboxylic acid anhydride (14.8 g, 0.072 mol) in THF under an inert atmosphere of N2 at room temperature. The dark solution is stirred at room temperature overnight and the resulting solid filtered off, washed with THF and air dried to give 17.35 g (72%) of 6-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]thieno[2,3-b]pyridine-5-carboxylic acid.

Quelle