Reaktion #343291

Reaktionsgleichung

1,8-diazabicyclo[5.4.0]undec-7-ene

2-mercaptopyrimidine

2-chloromethylbenzenesulfonamide

→

2-(2-sulfamoylphenylmethylthio)pyrimidine

Ausbeute 85.2%

Lösungsmittel

acetonitrile

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturWith cooling
2. 2
   SonstigeTo the yellowish solution so obtained
3. 3
   SonstigeThe precipitate is isolated by filtration
4. 4
   Sonstigedried

Vorschrift

With cooling, 7.9 g of 97% 1,8-diazabicyclo[5.4.0]undec-7-ene are added to a suspension of 5.7 g of 98% 2-mercaptopyrimidine in 50 ml of acetonitrile. To the yellowish solution so obtained are added 10.3 g of 2-chloromethylbenzenesulfonamide. The reaction solution is stirred for 70 hours at 20°-22° C. and then diluted with 1 liter of water. The precipitate is isolated by filtration and dried, affording 12.0 g (85% of theory) of 2-(2-sulfamoylphenylmethylthio)pyrimidine of m.p. 128°-130° C.

Quelle