Reaktion #343082

Reaktionsgleichung

sodium hydroxide

3-amino-phenacyl bromide hydrobromide

thioacetamide

dimethylformamide

→

2-methyl-4-(3-amino-phenyl)-thiazole

Ausbeute 79.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe precipitate was filtered off
2. 2
   Sonstigedried

Vorschrift

A mixture of 3-amino-phenacyl bromide hydrobromide (11.78 g), thioacetamide (3 g) and dimethylformamide (20 ml) was stirred at room temperature for 24 hours and then poured into water (100 ml). The resulting solution was made alkaline with 10% sodium hydroxide, and the precipitate was filtered off and dried to give 6 g of 2-methyl-4-(3-amino-phenyl)-thiazole; M.p. 134°-137° C.

Quelle