Reaktion #343003

Reaktionsgleichung

hydrochloric acid

sulfonamide

2-[5-(Methylthio)-1,3,4-oxadiazol-2-yl]benzenemethanesulfonamide

phenyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate

DBU

→

subject compound

Ausbeute 28.5%

N-[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-[5-(methylthio)-1,3,4-oxadiazol-2-yl]benzenemethanesulfonamide

Ausbeute 28.5%

Lösungsmittel

water

p-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltration
2. 2
   Waschenthe residue was washed with 1×5 ml of warm ethyl acetate

Vorschrift

By the procedure of Example 4, 0.62 g of the sulfonamide of Example 3 was reacted with 0.57 g of phenyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate and 0.33 g of DBU in 10 ml of p-dioxane. After stirring two hours at room temperature the solution was diluted with about 75 ml of water and acidified with concentrated hydrochloric acid (red to litmus). Following filtration, the residue was washed with 1×5 ml of warm ethyl acetate to give 0.28 g of the subject compound; m.p. 175°-177° C.

Quelle