Reaktion #3424

Reaktionsgleichung

HCl

7a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

→

title compound

Ausbeute 74.0%

7a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine hydrochloride salt

Ausbeute 74.0%

Lösungsmittel

Et2O

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed
2. 2
   Sonstigethe solid was triturated with Et2O
3. 3
   Sonstigedried

Vorschrift

7a-(5-chloro-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was triturated with Et2O and dried to afford the title compound as a white powder (35 mg, 74%): mp 181°-183° C.; 1H NMR (D2O, 300 MHz) δ2.15-2.50 (m, 6H), 2.56-2.65 2H), 3.34-3.42 (m, 2H), 3.79-3.87 (m, 2H), 8.24-8.29 (m, 2H); MS (CI/NH3) m/z: 241 (M+H)+ ; MS (CI/NH3): m/z 241/243 (M+H+). Anal. Calcd for C12H14 ClFN2.HCl: C, 52.00; H, 5.45; N, 10.11. Found: C, 51.81; H, 5.62; N, 9.84.

Quelle