Reaktion #342125

Reaktionsgleichung

water

1-(2-bromoethyl)-4-nitrobenzene

morpholine

K2CO3

→

title compound

4-[2-(4-Nitrophenyl)ethyl]morpholine

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe aqueous mixture was extracted with ether
2. 2
   WaschenThe organic layer was washed with brine
3. 3
   Trocknendried over MgSO4
4. 4
   Sonstigeevaporated in vacuo

Vorschrift

To a solution of 1-(2-bromoethyl)-4-nitrobenzene (460 mg, 2.0 mmol) in acetone (15 mL) was added morpholine (610 mg, 7.0 mmol) and 680 mg of K2CO3. The mixture was stirred for 80 hours at ambient temperature, and then poured into water. The aqueous mixture was extracted with ether. The organic layer was washed with brine, dried over MgSO4, and evaporated in vacuo to give 456 mg (1.93 mmol; 97%) of the title compound, which was converted to the appropriate amine by the method disclosed in Preparation 16.

Quelle