Reaktion #342018

Reaktionsgleichung

5-(4-chlorophenyl)-N-(2-cyclohexyl-2-oxoethyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

oxazole

Lawesson's reagent

→

title compound

Ausbeute 76.1%

2-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-5-cyclohexylthiazole

Ausbeute 76.1%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added to a microwave reactor
2. 2
   SonstigeThe capped reactor was placed in a microwave reactor
3. 3
   Sonstigethe mixture was irradiated at 1860° C. for 30 min
4. 4
   SonstigeThe reaction product was purified by reverse-phase prep HPLC

Vorschrift

5-(4-chlorophenyl)-N-(2-cyclohexyl-2-oxoethyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (116 mg, 0.23 mmol) obtained in Step 3 of preparation of oxazole was added to a microwave reactor containing Lawesson's reagent (186 mg, 0.46 mmol) in THF (2 mL). The capped reactor was placed in a microwave reactor and the mixture was irradiated at 1860° C. for 30 min. The reaction product was purified by reverse-phase prep HPLC to provide the title compound (88 mg, 76%) as white solid.

Quelle