Reaktion #3420

Reaktionsgleichung

HCl

7a-(5-methyl-3-pyridinyl)-hexahydro-1H-pyrrolizine

→

title compound

Ausbeute 87.0%

7a-(5-methyl-3-pyridinyl)-hexahydro-1H-pyrrolizine hydrochloride salt

Ausbeute 87.0%

Lösungsmittel

Et2O

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed
2. 2
   Sonstigethe solid was triturated with Et2O
3. 3
   Sonstigedried

Vorschrift

7a-(5-methyl-3-pyridinyl)-hexahydro-1H-pyrrolizine (109 mg, 0.54 mmol) was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was triturated with Et2O and dried to afford the title compound as a white powder (112 mg, 87%); mp 153°-154° C.; 1H NMR D2O, 300 MHz) δ2.12-2.49 (m, 9H), 2.57-2.66 (m, 2H), 3.34-3.43 (m, 2H), 3.79-3.87 (m, 2H), 7.90 (s, 1H), 8.46 (s, 1H), 8.52 (s, 1H); MS (CI/NH3) m/z: 203 (M+H)+ ; MS (CI/NH3): m/z 203 (M+H+), 220 (M+NH4+). Anal. Calcd for C13H18N2.1.4 HCl: C, 61.63; H, 7.72; N, 11.06. Found: C, 61.82; H, 7.89; N, 11.00.

Quelle