Reaktion #341970

Reaktionsgleichung

Sodium triacetoxyl-borohydride

5-bromo-pyridine-3-amine

3-cyclopentyloxy-4-methoxy-benzaldehyde

HOAc

→

5-bromo-N-(3-(cyclopentyloxy)-4-methoxybenzyl)pyridin-3-amine

Ausbeute 93.0%

Lösungsmittel

DCE

—

1,2-dichloroethtane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   WaschenThe organic phase was washed with water
3. 3
   Trocknendried over sodium sulfate
4. 4
   SonstigeThe solvent was removed by under reduced pressure

Vorschrift

Sodium triacetoxyl-borohydride (245 mg, 1.16 mmol) was added to the solution of 5-bromo-pyridine-3-amine (100 mg, 0.57 mmol) and 3-cyclopentyloxy-4-methoxy-benzaldehyde (127 mg, 0.57 mmol) in 10 ml of 1,2-dichloroethtane (DCE), of HOAc (66 μL, 2 eq. 1.16 mmol) was added, the mixture was stirred overnight at room temperature, followed by addition of 15 ml of DCE. The organic phase was washed with water, and dried over sodium sulfate. The solvent was removed by under reduced pressure to give 200 mg of crude 5-bromo-N-(3-(cyclopentyloxy)-4-methoxybenzyl)pyridin-3-amine, which was used for the next step without further purification.

Quelle