Reaktion #341759

ord-348278992a094d91904c1c1453a0cfa2

Reaktionsgleichung

CCc1c(Cl)ccc(F)c1CC1=NCCN1
2-(3-chloro-2-ethyl-6-fluoro-benzyl)-4,5-dihydro-1H-imidazole
CCc1c(Cl)ccc(F)c1CC1=NCCN1
2-(3-Chloro-2-ethyl-6-fluoro-benzyl)-4,5-dihydro-1H-imidazole
O=c1n(Cl)c(=O)n(Cl)c(=O)n1Cl
TCCA
C1CCC2=NCCCN2CC1
DBU
CCc1c(Cl)ccc(F)c1Cc1ncc[nH]1
2-(3-Chloro-2-ethyl-6-fluoro-benzyl)-1H-imidazole

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

2-(3-Chloro-2-ethyl-6-fluoro-benzyl)-1H-imidazole was prepared from 2-(3-chloro-2-ethyl-6-fluoro-benzyl)-4,5-dihydro-1H-imidazole (Example 198), TCCA and DBU in analogy to Example 194e): light yellow crystals; MS (ISP): 241.2 ([M+H]+, 58%), 239.2 ([M+H]+, 100%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07875645B2uspto-grants-2011_01