Reaktion #341497

Reaktionsgleichung

2,6-difluorobenzylbromide

1-(2-Chloro-phenyl)-3,4-dimethyl-7-hydroxy-imidazo(1,5-a)quinoxaline

Caesium carbonate

N,N-dimethylformamide

→

1-(2-Chloro-phenyl)-7-(2,6-difluorobenzyloxy)-3,4-dimethyl-imidazo(1,5-a)quinoxaline

Lösungsmittel

water

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered off
2. 2
   Waschenwashed with water
3. 3
   Sonstigedried under reduced pressure
4. 4
   Sonstigepurified with silica gel, dichloromethane/methanol=95/5

Vorschrift

1 g 1-(2-Chloro-phenyl)-3,4-dimethyl-7-hydroxy-imidazo(1,5-a)quinoxaline, 2.24 g Caesium carbonate, 50 mL N,N-dimethylformamide, and 6 mL water were stirred for 10 min followed by addition of 0.83 g 2,6-difluorobenzylbromide. After 3 h stirring at 130° C. the reaction mixture was given into 150 mL water, filtered off, washed with water, dried under reduced pressure, and purified with silica gel, dichloromethane/methanol=95/5.

Quelle