Reaktion #341137

Reaktionsgleichung

5-bromo-2-chloronicotinic acid

oxalyl chloride

→

5-bromo-2-chloropyridine-3-carbonyl chloride

Ausbeute 99.4%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenAfter 4 H the mixture was concentrated in vacuo

Vorschrift

To a slurry of 5-bromo-2-chloronicotinic acid (2.063 g, 8.725 mmol) in methylene chloride (20 mL) was slowly added oxalyl chloride (1.11 g, 8.725 mmol) followed by the addition of dimethylformamide (5 drops). After 4 H the mixture was concentrated in vacuo to provide 2.21 g of 5-bromo-2-chloropyridine-3-carbonyl chloride as a light brown solid, which was used as is in the next reaction.

Quelle